Pharmacovigilance is the science and activities associated with gathering, recognition, appraisal, checking, and counteractive action of untoward impacts with pharmaceutical items. Pharmacovigilance essentially safety of medicine. Pharmacists have key roles in wellbeing frameworks to keep up the reasonable and safe utilization of medicine for they are medicated specialists who are unequivocally prepared in this field. The perspective of drug store understudies on pharmacovigilance and adverse drug reaction (ADR) revealing has additionally been examined with an intend to center the need to improve content identified with ADR announcing and pharmacovigilance in undergrad drug store educational programs. Globally, despite the fact that the job of pharmacists inside national pharmacovigilance frameworks contrasts, it is exceptionally all around perceived. Reconciliation of ADR announcing ideas in instruction educational modules, preparing of pharmacists and deliberate commitment of pharmacists in ADR revealing is imperative in accomplishing the safety objectives and preservation of general wellbeing. Likewise, these learning holes can be placed through nonstop expert improvement projects and fortifying hypothetical and reasonable information in undergrade drug store educational programs. Without adequately distinguishing and acknowledging preparing requirements of pharmacists and other human services experts, the capability of national pharmacovigilance frameworks is probably not going to enhance which may trade off patient's safety. Purpose: Discussion and projection of present situation analysis and future demand for pharmacovigilance. The pharmacists have a vital role to play which is thoroughly discussed. Methodology: Research conducted a year-round comprehensive literature search, which included technical newsletters, newspapers journals, and many other sources. The present study was started at the beginning of 2018. PubMed, ALTAVISTA, Embase, Scopus, Web of Science, and the Cochrane Central Register of was thoroughly searched. The keywords were used to search for different publishers’ journals like Elsevier, Springer, Willey Online Library, Wolters Kluwer extensively were followed. Medicine and technical experts, pharma company delegates, hospital nurses and chemists were given their valuable suggestions. Predictions were based on estimates such as drug end users, providers or prescribers, general knowledge of rational use, consequence and types of different incidences of ADR and non-compliance, their management or overlooking. Studies regarding inclusion and information sources of pharmacovigilance were given priorities. Several factors that influence medication-taking behavior, non-compliance, ADR reporting by pharmacists were communally analyzed and added to the article. Issues regarding economic and cultural barriers were found to be different from subcontinents, countries and even states. Most significant features of pharmacists’ role in the therapeutic intervention were added afterward to maintain a logical sequence. Drug factors, environmental factors and provider-patient interaction followed by pharmacist's role in handling patients and to change or correction of medication counseling, dispensing, monitoring was added to reveal their effect on patient compliance which is the eventual goal of meeting therapeutic guidelines. Many studies found regarding pharmacists’ role in therapeutic cost minimization, role in hospital and other healthcare settings, disease prevention, and lifestyle management found to be not within the scope of this article. Findings: Pharmacists are an integral part of the healthcare management system, and the importance of their role play is not after doctors and nurses. Any future role for the pharmacist in counseling, monitoring and vigilance could be addressed as part of a formalized, strategic approach by creating an integrated healthcare team, with attention to further enhancement of pharmacovigilance in any country, community or a healthcare setting. Research limitations: Research has a major limitation with dealing too many information on pharmacovigilance worldwide. An only important aspect of the expanded role of pharmacists, the present situation of vigilance in different countries and a few future prospect, demand and provisions of pharmacists in meeting those emerging demands are discussed. Practical implication: The soul of this article was to detail about the present situation and future demands of pharmacovigilance. Along with students, researchers and professionals of different background and disciplines, e.g., pharmacists, marketers, doctors, nurses, hospital authorities, public representatives, policy makers, and regulatory authorities have to acquire much from this article. Social implication: The article should contribute an integrated guideline for patient compliance, demand pharmacovigilance and last but not the least a silver lining of better healthcare situation in near future.